London: Fatty liver disease is a major public health concern because it leads to serious and often fatal liver conditions, including cancer. Fatty liver, which is linked to obesity can lead to cirrhosis – where the liver shrinks and can lead to liver failure. The study, partly funded by the UK charity Worldwide Cancer Research, reveals for the first time that the protein CPEB4 can prevent fatty liver disease.
The results were published in Nature Cell Biology. Experts found the protein can act as a predictive marker – to pre-empt who might be at a higher risk of developing fatty liver. Dr. Fernández, co-lead of the study said: “Given the obesity epidemic in the US and Western world, an increase in those affected by non-alcoholic fatty liver disease is expected in the coming decades and we still do not have a suitable treatment for this condition.”
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If you have NASH, no medication is available to reverse the fat buildup in your liver. In some cases, the liver damage stops or even reverses itself. But in others, the disease continues to progress. If you have NASH, it’s important to control any conditions that may contribute to fatty liver disease.
The researchers managed to reverse fatty liver disease in mice by treatment with a drug called Tudca, which is already used to treat other liver disorders. Together these results could help prevent fatty liver disease in some people and pave the way for new treatments in the future, experts claim.
The lead author of the study, Carlos Maíllo, revealed that CPEB4 is essential to drive the liver’s response to stress. The protein allows the cell to ‘clean up the excess fat.
Dr. Raúl Méndez, said: “This new knowledge of CPEB4’s role in the liver could be particularly useful for people with variations of the protein.
“It could act as a predictive marker – to pre-empt who might be at a higher risk of developing fatty liver. “The knowledge could also then serve to help prevent fatty liver, for example, through improvements in a person’s diet and better choice of eating times.”
The researchers managed to reverse fatty liver disease in mice by treatment with a drug called Tudca, which treats other liver disorders. The drug exerted the same effect on the proteins that CPEB4 activates.
“Our findings could contribute to the development of new treatments. In the future it may be possible to design molecules like Tudca that specifically target CPEB4, thus enhancing the liver clean-up process,” said Dr. Méndez.
Dr. Lynn Turner, head of research at Worldwide Cancer Research said: “This research just goes to demonstrate the importance of funding early-stage research.
“The team in Barcelona are paving the way for future treatments and using their research to address one of the symptoms of a growing problem.” Jigar Ki Garmi aur Waram Ka Ilaj. Jigar Ki Charbi Ka Ilaj aur alamat. jigar ki kharabi ka desi ilaj Urdu
