People who take vitamin D supplements may be less at risk for developing late-stage and even fatal cancer, new research suggests. A study led by experts at Harvard University found people taking the daily pills were 17 percent less likely to develop advanced cancer. And those who were of a healthy weight were even more likely to benefit, with a risk reduction of 38 percent.
Vitamin D is primarily known for helping to regulate calcium and phosphate, minerals that are key to developing and maintaining healthy bones, teeth, and muscles. But in recent years, there’s been mounting evidence the vitamin D which we primarily absorb from sunlight is also involved in the life cycle and growth of many types of cells, including those that make up the immune system.
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The new Harvard research, published in the JAMA Network Open medical journal, overturns the initial findings of a study of 25,000 people published in 2018. Initially, researchers believed there was no benefit from taking vitamin D, as they detected no reduced incidence of cancer diagnoses overall.
But they were puzzled because cancer deaths went down among those taking the supplements. A secondary analysis, published last night, found this anomaly can be explained by the fact that vitamin D seems to stop metastatic cancers – those aggressive types which spread to other parts of the body.
Researcher Dr. Paulette Chandler, a primary care physician and epidemiologist at Harvard’s Brigham And Women’s Hospital in Boston, said: ‘Vitamin D is a supplement that’s readily available, cheap and has been used and studied for decades.
‘Our findings, especially the strong risk reduction seen in individuals with normal weight, provide new information about the relationship between vitamin D and advanced cancer.’ More than 25,000 people took part in the study, which spanned more than five years.
The participants included men aged 50 or above and women 55 or older who did not have cancer when the trial began.
The test subjects were divided into four groups – the first group took a daily dose of vitamin D along with omega-3s; the second group took vitamin D plus a dummy placebo, the third consumed omega-3s plus placebo, while the fourth group only had placebos.
The initial results showed no statistical difference in overall cancer rates but a reduction in cancer-related deaths was observed.
In their secondary analysis, Dr. Chandler and colleagues evaluated the risk of developing advanced cancer – late-stage and metastatic forms of the disease- among participants who did or did not take vitamin D supplements during the trial.
They also examined whether an individual’s body mass index played a role. Among the participants, 1,617 were diagnosed with an invasive form of cancer – such as breast, prostate, colorectal, lung – over the next five years.
Among those who received vitamin D, 226 were diagnosed with advanced cancer, compared to 274 who received the placebo. Of those of a healthy weight who took vitamin D, 58 people were diagnosed with advanced cancer compared with 96 taking the placebo. The team said they found no association between omega-3 fatty acid supplementation and advanced cancer. source dailymail